Floor-enhanced infrared absorption (SEIRA) results in a largely improved detection of polar molecules, in comparison with customary infrared absorption. The enhancement precept relies on localized floor plasmon resonances of the substrate, which match the frequency of molecular vibrations within the analyte of curiosity. Subsequently, in sensible phrases, the SEIRA sensor must be tailor-made to every particular analyte. We evaluation SEIRA sensors based mostly on steel plasmonics for the detection of biomolecules reminiscent of DNA, proteins, and lipids. We additional focus this evaluation on chemical SEIRA sensors, with potential purposes in high quality management, in addition to on the advance in sensor geometry that led to the event of multiresonant SEIRA substrates as sensors for a number of analytes. Lastly, we give an introduction into the combination of SEIRA sensors with surface-enhanced Raman scattering (SERS).