What is the difference between azathioprine and mercaptopurine?

The immunosuppressant of preference is typically azathioprine, but mercaptopurine, an active metabolite of azathioprine, may be tolerated if azathioprine therapy is unsuccessful. Mercaptopurine has been used for many years to treat inflammatory bowel disease despite not having a license to do so and in accordance with national guidelines.

Is 6-mercaptopurine the same as azathioprine?

Patients with inflammatory bowel disease (IBD) who are unable to maintain remission when glucocorticoids are tapered and withdrawn benefit from the glucocorticoid-sparing effects of thiopurines, such as azathioprine [AZA] and mercaptopurine, also known as 6-mercaptopurine [6-MP].

How is mercaptopurine created from azathioprine?

Before becoming active, azathioprine is metabolized in the liver. One method of metabolism involves converting it to 6-mercaptopurine, whose active metabolite is 6-thioinosinic acid. Separate from 6-mercaptopurine, other metabolic pathways also break down azathioprine.

Does azathioprine undergo mercaptopurine metabolization?

metabolism of azathioprine (AZA). Hypoxanthine phosphoribosyltransferase catalyzes the first step in the mercaptopurine (6MP) nucleotide metabolite formation (HPRT). Thioguanine nucleotides are eventually produced by the further metabolism of mercaptopurine nucleotide (TGNs).

Does mercaptopurine damage the liver?

Additionally, mercaptopurine can cause a distinct acute, clinically noticeable liver injury that typically manifests 1 to 6 months after the start of treatment with fatigue, jaundice, and an elevated cholestasis- or mixed-pattern of serum enzymes, but can occur later, especially after a dose increase.

How long should you take azathioprine for?

How long do I intend to use it? You could take azathioprine for up to 5 years if it is tolerated. Even if you feel fine, keep taking your medication unless your doctor instructs you to.

Does mercaptopurine impair the body’s defenses?

What is this drug, exactly? A chemotherapy medication is called MERCAPTOPURINE, 6-MP (mer kap toe PYOOR een). It can lower immune system activity and hinder the growth of cancer cells.

The long-term safety of mercaptopurine is .

If azathioprine or mercaptopurine works well for you, you should be able to continue taking it for a while as long as your monitoring blood test results are satisfactory and you don’t experience any severe adverse reactions.

What occurs if you don’t take azathioprine anymore?

If you stop using it abruptly while receiving this medication for a kidney transplant, you run the risk of experiencing transplant rejection and kidney failure. Your RA symptoms might return if you are taking this medication for it and stop suddenly.

What conditions does mercaptopurine treat?

Acute lymphoblastic leukemia is maintained with the help of mercaptopurine and other medications. It is a member of the class of drugs known as antimetabolites. Cancer cells are eventually eliminated as a result of mercaptopurine’s interference with their growth.